Demo Run Load demo data Job name Email (links to the results will be sent to your mail-box)

Upload your GWAS data Select data type SNP    Gene GWAS file    -logarithm transformation (necessary ONLY for P-value data)

Select mapping rules of SNPs->genes 500 kb upstream and downstream of gene 100 kb upstream and downstream of gene 20 kb upstream and downstream of gene 5 kb upstream and downstream of gene within gene Specify mapping rule kb upstream and downstream of gene Please input an integer between 0 and 500, default value is 20.

Gene set database BioCarta pathways KEGG pathways ( to include pathways representing disease directly NO YES )  GO biological process GO molecular function GO cellular component OR upload your own gene sets file Number of genes in gene set     Minimum (typical 5-20) Maximum (typical 200-inf) Advanced options for gene set database Limit gene sets by keyword (e.g. immune). The keyword can be gene name (e.g. CD4) Keyword include    exclude Mask MHC/xMHC region NO    mask MHC    mask xMHC

Functional analysis Yes     No Select LD data source 1000 Genome population: EUR AMR ASN AFR HapMap III population: CEU CHB JPT YRI ASW CHD GIH LWK MEX MKK TSI Select functional data source Ensembl putative functional variants ENCODE regulatory feature peaks: Data Type: DNase-seq Peaks FAIRE Peaks TFBS Peaks (PeakSeq) TFBS Peaks (SPP) Histone Peaks Tissue: -------All------- blastula blood bone brain breast cerebellar cervix colon connective embryonic epithelium eye fetal foreskin gingiva gingival heart induced kidney liver luminal lung mammary monocytes muscle myometrium pancreas pancreatic prostate skin spinal testis urothelium uterus Expression quantitative trait loci (eQTLs)